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apalutamide will decrease the extent or outcome of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medicine that are CYP2C19 substrates may lead to reduced publicity to those remedies.Just before use, instruct personal administering diazepam intr